Conference "New insights in regenerative therapies"

4 czerwca 2019

9:00-9:10

Welcome by Professor Grzegorz Gielerak, Director of WIM

9:10-9:30

Opening/Introduction: Eva Jakab-Toth, Jozef Dulak, Claudine Kieda

9:30-11:05

Session I - New technological Approaches for Imaging and Therapy

Chair: Eva Jakab-Toth

09:30

09:50

Lecture 1: Pierre Savagner: EMT pathway roles during tumor progression and resistance in 3D organized breast cancers models

09:50

10:10

Lecture 2: Amanda Brun: Extracellular vesicle production and engineering for therapy: physical stimulation for boosting yield

10:10

10:30

Lecture 3: Sara Martins Vasco de Lacerda: Peptide-base targeted contrast agents: Novel probes for dysfunctional elastogenesis and metastasis imaging

10:30

10:50

Lecture 4: Stephane Petoud: Near-infrared emitting bioanalytical and optical imaging probes based on lanthanide compounds

10:50

11:05

Lecture 5: Guillaume Collet: Creation of a new class of MOF for drug delivery

11:05-11:35

Coffee Break

11:35-13:10

Session II - Microenvironment in pathologies development

Chair: Józef Dulak

11:35

11:55

Lecture 6: Marta Miączyńska: Synthetic lethality between VPS4A and VPS4B in colorectal cancer

11:55

12:15

Lecture 7: Alicja Józkowicz: Role of heme oxygenase-1 in melanoma and melanoma initiating cells

12:15

12:35

Lecture 8: Claudine Kieda: Angiogenesis targeted therapies in tumor and its microenvironment

12:35

12:55

Lecture 9: Monika Biniecka: Altered angiogenesis and bioenergetics in RA synovium in response to hypoxia

12:55

13:10

Lecture 10: Monika Jakubowska: Nrf2 modulates pancreatic tumor growth in the orthopic mouse model

13:10-15:00

Lunch / Workshop on new applied technologies

Chair: Halina Waś

15:00-16:10

Session III - Stem cells: differentiation and therapy

Chair: Chantal Pichon

15:00

15:20

Lecture 11: Krzysztof Szade: Understanding the aging of hematopoietic stem cells - toward novel clinical applications

15:20

15:35

Lecture 12: Izabella Skulimowska: Where do the hematopoietic stem cells live - the bone marrow niche

15:35

15:55

Lecture 13: Jacek Kubiak: Regenerative potential of mesenchymal stem cells (MSCs) is affected by hexachlorophen

15:55

16:10

Lecture 14: Witold Nowak: Lack of both heme oxygenases in mammalian cells - what doesn’t kill you makes you stronger?

16:10-16:40

Coffee Break

16:40-17:50

Session IV - The potential of stem cell based new therapies

Chair: Helene Benedetti

16:40

17:00

Lecture 15: Józef Dulak: Engineering of human induced pluripotent stem cells derived cardiomyocytes for therapy

17:00

17:20

Lecture 16: Edyta Brzóska-Wójtowicz: The muscle interstitial cells - what they are in mouse and human

17:20

17:35

Lecture 17: Kalina Andrysiak: hIPSC-derived cardiomyocytes and organs-on-a-achip as tools for heart disease modelling

17:35

17:50

Lecture 18: Neli Kachamakova-Trojanowska: Modeling maturity onset diabetes of the young (MODY) or could mutations in HNF1A gene lead to endothelial dysfunction

5 czerwca 2019

9:00-10:30

Workshop on scientific cooperation

Moderator: Christophe Paoli, Attaché for science and academic cooperation, Embassy of France in Poland

10:30-11:00

Coffee Break / Poster Session

11:00-12:40

Session V - Understanding the physiologic and pathologic niches

Chair: Claudine Kieda

11:00

11:20

Lecture 19: Agnieszka Łoboda: Dysregulation of angiogenesis contributes to the progression of Duchenne muscular dystrophy – the role of heme oxygenase-1

11:20

11:35

Lecture 20: Paulina Podkalicka: microRNA-378 in a mice model of Duchenne muscular dystrophy – a weapon against hallmark symptoms of the disease?

11:35

11:55

Lecture 21: Anna Grochot-Przęczek: Loss of Nrf2 transcriptional activity induces Marfan-like phenotype in murine aorta

11:55

12:10

Lecture 22: Mohammed Bergoug: Neurofibromin a new SUMO target involved in neurofibromatosis type 1 disease

12:10

12:25

Lecture 23: Maria Paprocka: Increased number of EPC cells in early or endometrial cancer

12:25

12:40

Lecture 24: Jullien Cros: Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy

12:40-13:40

Lunch

13:40-15:25

Session VI - Microenvironment: focus on cancer

Chair: Stephane Petoud

13:40

14:00

Lecture 25: Martyna Elas: Electron paramagnetic resonance oximetry and redox capacity in tumors in vivo

14:00

14:15

Lecture 26: Klaudia Brodaczewska: MDSC in tumor immune regulation and modulation by hypoxia

14:15

14:35

Lecture 27: Halina Waś: Autophagy modulation restores proliferative potential of senescent cancer cells

14:35

14:55

Lecture 28: Małgorzata Brindell: Targeting of hypoxia cells for imaging and therapy

14:55

15:10

Lecture 29: Aleksandra Ellert-Miklaszewska: Efficient and innocuous delivery of siRNA to microglia using an amphiphilic dendrimer nanovector

15:10

15:25

Lecture 30: Róża Pietrzycka: Regnase-1 in the skin cancer development

15:25-15:55

Coffee Break / Poster Session

15:55-17:25

Session VII - RNA biomarkers and therapeutics

Chair: Alicja Józkowicz

15:55

16:15

Lecture 31: Christophe Denoyelle & Nicolas Vigneron: Towards a new standardized method for circulating miRNAs profiling in clinical studies: Interest of the exogenous normalization to improve miRNA signature accuracy

16:15

16:35

Lecture 32: Chantal Pichon: New insights on miR-21-3p in regulation and function in keratinocytes under steady state and psoriatic conditions

16:35

16:55

Lecture 33: Magdalena Chechlińska: Cancer field effect – new issues and new directions for biomarker studies

16:55

17:10

Lecture 34: Elodie Henriet: Cellular platforms for HTS screening of miRNA

17:10

17:25

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